GOP House leader calls Senate immigration bill a 'pipe dream' (CNN)

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Fed bond-buying could be more aggressive than new timeline: Dudley

By Jonathan Spicer

NEW YORK (Reuters) - The Federal Reserve's asset purchases would be more aggressive than the timeline Chairman Ben Bernanke outlined last week if economic growth and the labor market turn out weaker than expected, the influential head of the New York Fed said on Thursday.

Pushing back hard against market concerns over the withdrawal of quantitative easing, William Dudley stressed in a speech that the newly adopted timeline for reducing the pace of bond buying depends not on calendar dates but on the economic outlook, which remains quite unclear.

Turning to the question of when the Fed will ultimately raise interest rates, Dudley, a close ally of Bernanke, went so far as to say that recent market expectations for an earlier rate rise are "quite out of sync" with the statements and expectations of the policy-making Federal Open Market Committee.

"Economic circumstances could diverge significantly from the FOMC's expectations," Dudley said according to prepared remarks.

"If labor market conditions and the economy's growth momentum were to be less favorable than in the FOMC's outlook ? and this is what has happened in recent years ? I would expect that the asset purchases would continue at a higher pace for longer."

Following a Fed policy meeting last week, Bernanke surprised markets by saying the central bank expected to reduce the $85-billion monthly pace of bond buying later this year and to end the QE3 program altogether by mid-2014, if the economy improves as expected.

Global markets have since fallen sharply, with yields on the 10-year U.S. Treasury spiking to near a two-year high.

Dudley repeated and backed the timeline Bernanke articulated last Wednesday. But he appeared to want to bolster efforts by some of his Fed colleagues this week to calm investors' worries that less Fed accommodation will hurt the slow U.S. and global economic recovery.

The labor market, which the Fed is targeting with QE3, "still cannot be regarded as healthy," Dudley said, adding "there remains a great deal of slack in the economy."

He expects about 2.1 percent Gross Domestic Product growth this year, about the same as it has been since the recession ended in 2009. But Dudley expects that to pick up next year.

Frustrated with fitful U.S. recovery from the Great Recession, the central bank has kept the federal funds rate near zero since late 2008 and has promised to keep it there at least until the unemployment rate falls to 6.5 percent, from 7.6 percent now, as long as inflation stays below 2.5 percent.

Even under the timeline for reducing QE3, "a rise in short-term rates is very likely to be a long way off," Dudley said.

"Not only will it likely take considerable time to reach the FOMC's 6.5 percent unemployment rate threshold, but also the FOMC could wait considerably longer before raising short-term rates," he said.

(Reporting by Jonathan Spicer; Editing by Chizu Nomiyama)

Source: http://news.yahoo.com/fed-bond-buying-could-more-aggressive-timeline-dudley-142837206.html

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Simple two-drug combination proves effective in reducing risk of stroke

June 26, 2013 ? Results of a Phase III clinical trial showed that a simple drug regimen of two anti-clotting drugs -- clopidogrel and aspirin -- lowered the risk of stroke by almost one-third, compared to the standard therapy of aspirin alone, when given to patients who had minor or transient stroke symptoms to prevent subsequent attacks.

Described this week in the New England Journal of Medicine (July 4, 2013 print issue), the clinical trial was conducted at multiple sites in China and designed in partnership with a physician at UC San Francisco.

The trial involved 5,170 people who were hospitalized after suffering minor ischemic strokes or stroke-like events known as transient ischemic attacks, or TIAs, in which blood flow to the brain is briefly blocked. All patients were randomized into two groups and treated for three months with either aspirin alone or aspirin plus clopidogrel, which is marketed as Plavix. The three-month period following stroke is considered the most critical for medical intervention.

Overall, 8.2 percent of patients taking both drugs suffered subsequent strokes in the three months of follow-up compared to 11.7 percent of patients taking aspirin alone.

"The results were striking," said S. Claiborne Johnston, MD, PhD, a professor of neurology and associate vice chancellor of research at UCSF who was a senior author on the study.

The Chinese trial, called CHANCE (Clopidogrel in High-risk Patients with Acute Non-disabling Cerebrovascular Events), is nearly identical to a National Institutes of Health-sponsored trial that is already enrolling patients in the United States, including at UCSF, called POINT (Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke).

"If POINT confirms CHANCE, then we're done -- the two-drug combination becomes the standard of care," said Johnston. "Anybody with a transient ischemic attack or minor stroke will get clopidogrel plus aspirin."

The POINT trial is important, said Johnston, because genetics, risk factors, and medical practice differences could all lead to differences in trial results in China compared to other countries. Johnston is the principal investigator of the POINT trial.

Stroke in China and the United States

Stroke is a leading cause of death and disability worldwide and is the fourth leading cause of death in the United States.

More than 795,000 people in the United States have strokes every year, and, in 2008 alone, some 133,000 cases were fatal, according to the U.S. Centers for Disease Control and Prevention. Another 300,000 people in the United States have TIAs each year.

Many strokes are minor -- shorter in duration than a full-blown stroke and usually have no lingering health impacts. In China, for instance, about 3 million new strokes occur every year, and about 30 percent of them are minor.

The protocol for the CHANCE trial was developed by Johnston and colleagues at Tiantan Hospital in China. The lead author of the study was Yongjun Wang, MD, of Beijing Tiantan Hospital.

China has many times more people who have strokes every year than the United States because of the size of the population and higher stroke rates, which allowed investigators to screen 41,561 patients in just three years at the 114 clinical sites, and enroll 5,170 patients in the trial.

Increased Risk of Subsequent Stroke

The reason for minor attacks is much the same as a full-blown stroke: a blood clot causes a blockage in the blood vessels that feed oxygen-rich blood to the brain. But in patients with TIAs and many minor strokes, the clot quickly goes away, usually in a few minutes, due to the natural mechanisms in the human body that are designed to deal with such clots.

However, in the weeks following a TIA or minor stroke, there is great risk that another clot will form, causing additional strokes -- potentially major ones. About 10 to 20 percent of people who have a TIA or minor stroke go on to have a subsequent stroke within three months.

Because of this risk, the first 90 days after a stroke or TIA is the most critical window for medical intervention. Currently, people who have minor strokes or TIAs are initially treated with aspirin alone. The purpose of the CHANCE trial was to determine whether clopidogrel with aspirin was more effective than aspirin alone in this intervention.

The drugs basically work the same way. They are "antiplatelet" agents, which target clotting agents found in the bloodstream know as platelets, preventing their aggregation. The combination is used commonly in patients who have heart attacks, but there has been no adequate clinical data to suggest it would work in stroke.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/df9E4AC9RSc/130626184021.htm

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Zebrafish study paves the way for new treatments for genetic disorder

June 26, 2013 ? Scientists from the University of Sheffield have paved the way for new treatments for a common genetic disorder thanks to pioneering research on zebrafish -- an animal capable of mending its own heart.

Charcot Marie Tooth disease (CMT) is the most common genetic disorder affecting the nervous system. More than 20,000 people in the UK suffer from CMT, which typically causes progressive weakness and long-term pain in the feet, leading to walking difficulties. There is currently no cure for CMT.

A research project conducted at the Sheffield Institute for Translational Neuroscience (SITraN) and the MRC Centre for Developmental and Biomedical Genetics (CDBG) by Dr Andrew Grierson and his team has revealed that zebrafish could hold the key to finding new therapeutic approaches to treat the condition.

Dr Grierson said: "We have studied zebrafish with a genetic defect that causes CMT in humans. The fish develop normally, but once they reach adulthood they start to develop difficulties swimming.

"By looking at the muscles of these fish we have discovered that the problem lies with the connections between motor neurons and muscle, which are known to be essential for walking in humans and also swimming in fish."

CMT represents a group of neurodegenerative disorders typically characterised by demyelination (CMT1), a process which causes damage to the myelin sheaths that surround our neurons, or distal axon degeneration (CMT2) of motor and sensory neurons. The distal axon is the terminal where neurotransmitter packages within neurons are docked.

The majority of CMT2 cases are caused by mutations in mitofusin 2 (MFN2), which is an essential gene encoding a protein responsible for fusion of the mitochondrial outer membrane. Mitochondria are known as the cellular power plants because they generate most of the supply of adenosine triphosphate (ATP), which is used as a source of chemical energy.

Dr Grierson said: "Previous work on this disorder using mammalian models such as mice has been problematic, because the mitofusin genes are essential for embryonic development. Using zebrafish we were able to develop a model with an adult onset, progressive phenotype with predominant symptoms of motor dysfunction similar to CMT2.

"Motor neurons are the largest cells in our bodies, and as such they are highly dependent on a cellular transport system to deliver molecules through the long nerve cell processes which connect the spinal cord to our muscles. We already know that defects in the cellular transport system occur early in the development of diseases such as Alzheimer's disease, Motor Neuron Disease and spastic paraplegia. Using our zebrafish model we have found that similar defects in transport are also a key part of the disease process in CMT."

Dr Grierson and his team are now seeking funding to identify new treatments for CMT using the zebrafish model. Because of their size and unique biology, zebrafish are ideal to be used in drug screens for the identification of new therapies for untreatable human conditions.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/AGpvAXqKerU/130626184023.htm

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Defense Of Marriage Act: Supreme Court Crowd Erupts In Cheers Over Ruling

WASHINGTON, DC - JUNE 26: Married couple Michael Knaapen (L) amd John Becker (2nd L) react after hearing the U.S. Supreme Court ruled that the Defense of Marriage Act (DOMA) is unconstitutional at the Supreme Court, June 26, 2013 in Washington, DC. The high court ruled to strike down DOMA and determined the California's proposition 8 ban on same-sex marriage was not properly before them, declining to overturn the lower court's striking down of the law. (Photo by Mark Wilson/Getty Images)

WASHINGTON, DC - JUNE 26: Married couple Michael Knaapen (L) amd John Becker (2nd L) kiss after hearing the U.S. Supreme Court ruled that the Defense of Marriage Act (DOMA) is unconstitutional at the Supreme Court, June 26, 2013 in Washington, DC. The high court ruled to strike down DOMA and determined the California's proposition 8 ban on same-sex marriage was not properly before them, declining to overturn the lower court's striking down of the law. (Photo by Mark Wilson/Getty Images)

Michael Knaapen, left, and his husband John Becker, right, embrace outside the Supreme Court in Washington, Wednesday, June 26, 2013, after the court cleared the way for same-sex marriage in California by holding that defenders of California's gay marriage ban did not have the right to appeal lower court rulings striking down the ban. (AP Photo/Charles Dharapak)

NEW YORK, NY - JUNE 26: Richelle Spanover (2nd R) wipes her eye after after the Supreme Court ruled key portions of the Defense of Marriage Act (DOMA) unconstitutional, at the Stonewall Inn on June 26, 2013 in the West Village neighborhood of New York City. The Stonewall Inn became historically important in the Lesbian-Gay-Bigender-Transgender community after playing a key role during the Gay-rights movement of the 1960s and 1970s. The high court ruled to strike down DOMA and determined the California's proposition 8 ban on same-sex marriage was not properly before them, declining to overturn the lower court's striking down of the law. (Photo by Andrew Burton/Getty Images)

NEW YORK, NY - JUNE 26: Virginia Sin (L) and Gretchen Menter smile after the Supreme Court ruled key portions of the Defense of Marriage Act (DOMA) unconstitutional, at the Stonewall Inn on June 26, 2013 in the West Village neighborhood of New York City. The Stonewall Inn became historically important in the Lesbian-Gay-Bigender-Transgender community after playing a key role during the Gay-rights movement of the 1960s and 1970s. The high court ruled to strike down DOMA and determined the California's proposition 8 ban on same-sex marriage was not properly before them, declining to overturn the lower court's striking down of the law. (Photo by Andrew Burton/Getty Images)

Edith Windsor, center, accompanied by her attorney Robert Kaplan, right, is greeted by Orie Urami, left, as she arrives at the LGBT Center for a news conference, in New York, Wednesday, June 26, 2013. In a major victory for gay rights, the Supreme Court on Wednesday struck down a provision of a federal law denying federal benefits to married gay couples and cleared the way for the resumption of same-sex marriage in California. (AP Photo/Richard Drew)

David Boies, an attorney arguing in support of gay marriage, speaks to the media after the U.S. Supreme Court overturned the Defense of Marriage Act (DOMA) and declined to rule on the California law Proposition 8 in Washington, D.C., U.S. on Wednesday, June 26, 2013. A divided U.S. Supreme Court gave a landmark victory to the gay-rights movement, striking down a federal law that denies benefits to same-sex married couples and clearing the way for weddings to resume in California. Photographer: Joshua Roberts/Bloomberg via Getty Images

Chris Roe (L) and Roby Chavez (R) celebrate while holding their soon-to-be adopted children as the US Supreme Court ruling is announced on June 26, 2013. The US Supreme Court struck down The Defense of Marriage Act (DOMA) today, and declared that same-sex couples who are legally married deserve equal rights to the benefits under federal law that go to all other married couples. In another ruling, the Supreme Court cleared the way for same-sex marriages to resume in California as the justices, in a prcedural ruling, turned away the defenders of Proposition 8. AFP PHOTO/Josh Edelson (Photo credit should read Josh Edelson/AFP/Getty Images)

Edith Windsor arrives at the LGBT Center for a news conference, in New York, Wednesday, June 26, 2013. In a major victory for gay rights, the Supreme Court on Wednesday struck down a provision of a federal law denying federal benefits to married gay couples and cleared the way for the resumption of same-sex marriage in California. (AP Photo/Richard Drew)

Edith Windsor reacts during a news conference at the LGBT Center, in New York, Wednesday, June 26, 2013. In a major victory for gay rights, the Supreme Court on Wednesday struck down a provision of a federal law denying federal benefits to married gay couples and cleared the way for the resumption of same-sex marriage in California. (AP Photo/Richard Drew)

Kris Perry, second from right, kisses her partner Sandy Stier outside the Supreme Court in Washington, Wednesday, June 26, 2013, after the court cleared the way for the resumption of same-sex marriage in their home state of California. From left are, plaintiffs Jeff Zarrillo, and his partner Paul Katami, attorney David Boies, plaintiffs Sandy Stier and Kris Perry, and attorney Ted Boutrous. (AP Photo/J. Scott Applewhite)

John Lewis, left, and Stuart Gaffney embrace outside San Francisco's City Hall shortly before the U.S. Supreme Court ruling cleared the way for same-sex marriage in California on Wednesday, June 26, 2013. The justices issued two 5-4 rulings in their final session of the term. One decision wiped away part of a federal anti-gay marriage law that has kept legally married same-sex couples from receiving tax, health and pension benefits. The other was a technical legal ruling that said nothing at all about same-sex marriage, but left in place a trial court's declaration that California's Proposition 8 is unconstitutional. (AP Photo/Noah Berger)

Sandy Stier, center, and her partner Kris Perry, right, plaintiffs in Hollingsworth v. Perry, the California Proposition 8 case, meets with reporters outside the Supreme Court in Washington, Wednesday, June 26, 2013, after the court's 5-4 decision that cleared the way for the resumption of same-sex marriage in their home state of California. Gesturing at far left is fellow plaintiff Jeff Zarrillo. (AP Photo/J. Scott Applewhite)

WASHINGTON, DC - JUNE 26: American University students Sharon Burk (L) and Mollie Wagoner (R) embrace after hearing that the U.S. Supreme Court ruled that the Defense of Marriage Act (DOMA) is unconstitutional at the Supreme Court, June 26, 2013 in Washington, DC. The high court ruled to strike down DOMA and determined the California's proposition 8 ban on same-sex marriage was not properly before them, declining to overturn the lower court's striking down of the law. (Photo by Mark Wilson/Getty Images)

John Lewis, left, and his partner Stuart Gaffney embrace as they react next to Andrea Shorter after the Supreme Court decision at the office of San Francisco Mayor Ed Lee at City Hall in San Francisco, Wednesday, June 26, 2013. The Supreme Court on Wednesday struck down a provision of a U.S. law denying federal benefits to married gay couples and cleared the way for the resumption of same-sex marriage in the state of California. The justices issued two 5-4 rulings in their final session of the term. One decision wiped away part of a federal anti-gay marriage law that has kept legally married same-sex couples from receiving tax, health and pension benefits. The other was a technical legal ruling that said nothing at all about same-sex marriage, but left in place a trial court's declaration that California's Proposition 8 is unconstitutional. (AP Photo/Jeff Chiu)

SAN FRANCISCO, CA - JUNE 26: Same-sex couple Jewelle Gomez (R) and Diane Sabin react upon hearing the U.S. Supreme Court's rulings on gay marriage in City Hall June 26, 2013 in San Francisco, California. The high court struck down the Defense of Marriage Act (DOMA) and ruled that supporters of California's ban on gay marriage, Proposition 8, could not defend it before the Supreme Court. (Photo by Justin Sullivan/Getty Images)

Gay rights activist Bryce Romero, who works for the Human Rights Campaign, offers an enthusiastic high-five to visitors getting in line to enter the Supreme Court on a day when justices are expected to hand down major rulings on two gay marriage cases that could impact same-sex couples across the country, in Washington, Wednesday, June 26, 2013. (AP Photo/J. Scott Applewhite)

Gay rights activist Bryce Romero, who works for the Human Rights Campaign, offers an enthusiastic high-five to visitors getting in line to enter the Supreme Court on a day when justices are expected to hand down major rulings on two gay marriage cases that could impact same-sex couples across the country, in Washington, Wednesday, June 26, 2013. (AP Photo/J. Scott Applewhite)

WASHINGTON, DC - JUNE 26: Attorney David Boise (C) speaks while flanked by plantiff couples Paul Katami, (L), Jeff Zarillo (2nd L), Sandy Steier (2nd R) and Kris Perry (R) after the U.S. Supreme Court ruled that part of the Defense of Marriage Act (DOMA) is unconstitutional at the Supreme Court, June 26, 2013 in Washington, DC. The high court ruled to strike down DOMA and determined the California's proposition 8 ban on same-sex marriage was not properly before them, declining to overturn the lower court's striking down of the law. (Photo by Mark Wilson/Getty Images)

Plaintiffs in Hollingsworth v. Perry, the California Proposition 8 case, react on steps of the Supreme Court in Washington, Wednesday, June 26, 2013, after justices cleared the way for the resumption of same-sex marriage in California. From left are, Jeff Zarrillo, and his partner Paul Katami, attorney David Boies, and Sandy Stier and her partner Kris Perry. (AP Photo/J. Scott Applewhite)

Michael Knaapen (L) and his husband John Becker react outside the US Supreme Court in Washington DC on June 26, 2013. The US Supreme Court on Wednesday struck down a controversial federal law that defines marriage as a union between a man and a woman, in a major victory for supporters of same-sex marriage.The Defense of Marriage Act (DOMA) had denied married gay and lesbian couples in the United States the same rights and benefits that straight couples have long taken for granted. AFP PHOTO / MLADEN ANTONOV (Photo credit should read MLADEN ANTONOV/AFP/Getty Images)

WASHINGTON, DC - JUNE 26: Chase Hardin hugs friend Kai Neander on the steps of the Supreme Court after favorable rulings were issued in same sex marriage cases June 26, 2013 in Washington, DC. The high court ruled to strike down DOMA and determined the California's proposition 8 ban on same-sex marriage was not properly before them, declining to overturn the lower court's striking down of the law. (Photo by Win McNamee/Getty Images)

WASHINGTON, DC - JUNE 26: Gay rights supporter Jay Norris, of New York City, holds a U.S. flag outside the U.S. Supreme Court building on June 26, 2013 in Washington, DC. The high court is expected to rule on the DOMA and Prop 8 gay marriage cases. (Photo by Win McNamee/Getty Images)

WEST HOLLYWOOD, CA - JUNE 26: Martha Acevedo, 25, celebrates the Supreme Court ruling after a watch party at Equality California, a non-profit civil rights organization that advocates for the rights of LGBT people in California, on June 26, 2013 in West Hollywood, California. The high court struck down the Defense of Marriage Act (DOMA) and ruled that supporters of California's ban on gay marriage, Proposition 8, could not defend it before the Supreme Court. (Photo by Kevork Djansezian/Getty Images)

Ellen Pontac, left, and her wife Shelly Bailes, celebrate in Sacramento, Calif., after the U.S. Supreme Court's ruling on gay marriage in California, Wednesday, June 26, 2013. The 5-4 decision wiped away part of a federal anti-gay marriage law that has kept legally married same-sex couples, like Pontac and Bailes, from receiving tax, health and pension benefits. (AP Photo/Rich Pedroncelli) will now have the same (AP Photo/Rich Pedroncelli)

Attendees at a watch party in Miami celebrate after the U.S. Supreme Court's ruling on gay marriage in California Wednesday, June 26, 2013. The justices issued two 5-4 rulings in their final session of the term. One decision wiped away part of a federal anti-gay marriage law that has kept legally married same-sex couples from receiving tax, health and pension benefits. The other was a technical legal ruling that said nothing at all about same-sex marriage, but left in place a trial court's declaration that California's Proposition 8 is unconstitutional. (AP Photo/Wilfredo Lee)

Julia Tate, left, kisses her wife, Lisa McMillin, as they read results of Supreme Court decisions regarding gay rights on Wednesday, June 26, 2013, in Nashville, Tenn. The justices issued two 5-4 rulings in their final session of the term. One decision wiped away part of a federal anti-gay marriage law that has kept legally married same-sex couples from receiving tax, health and pension benefits. The other was a technical legal ruling that said nothing at all about same-sex marriage, but left in place a trial court's declaration that California's Proposition 8 is unconstitutional. McMillin holds the couple's son, Luke. (AP Photo/Mark Humphrey)

Juan Talavera, right, kisses his partner Jeff Ronci after the announcement of the U.S. Supreme Court's ruling at a watch party in Miami, Wednesday, June 26, 2013. The justices issued two 5-4 rulings in their final session of the term. One decision wiped away part of a federal anti-gay marriage law that has kept legally married same-sex couples from receiving tax, health and pension benefits. The other was a technical legal ruling that said nothing at all about same-sex marriage, but left in place a trial court's declaration that California's Proposition 8 is unconstitutional. (AP Photo/Wilfredo Lee)

Renata Moreira, right, and partner Lori Bilella cheer after the U.S. Supreme Court's ruling on gay marriage in California, at San Francisco's City Hall on Wednesday, June 26, 2013. The justices issued two 5-4 rulings in their final session of the term. One decision wiped away part of a federal anti-gay marriage law that has kept legally married same-sex couples from receiving tax, health and pension benefits. The other was a technical legal ruling that said nothing at all about same-sex marriage, but left in place a trial court's declaration that California's Proposition 8 is unconstitutional. The couple plans to marry. (AP Photo/Noah Berger)

WEST HOLLYWOOD, CA - JUNE 26: Erica Ikeda (C), 26, and Jessica Parral (R), 24, react to the Supreme Court ruling at a watch party at Equality California, a non-profit civil rights organization that advocates for the rights of LGBT people in California, on June 26, 2013 in West Hollywood, California. The high court struck down the Defense of Marriage Act (DOMA) and ruled that supporters of California's ban on gay marriage, Proposition 8, could not defend it before the Supreme Court. (Photo by Kevork Djansezian/Getty Images)

WEST HOLLYWOOD, CA - JUNE 26: Brandon Benoit (C) hugs Martha Acevedo (L), 25, and Briana Castaneda, 23, as they celebrate the Supreme Court ruling at a watch party at Equality California, a non-profit civil rights organization that advocates for the rights of LGBT people in California, on June 26, 2013 in West Hollywood, California. The high court struck down the Defense of Marriage Act (DOMA) and ruled that supporters of California's ban on gay marriage, Proposition 8, could not defend it before the Supreme Court. (Photo by Kevork Djansezian/Getty Images)

WEST HOLLYWOOD, CA - JUNE 26: People celebrate in the street after the Supreme Court ruling at a watch party at Equality California, a non-profit civil rights organization that advocates for the rights of LGBT people in California, on June 26, 2013 in West Hollywood, California. The high court struck down the Defense of Marriage Act (DOMA) and ruled that supporters of California's ban on gay marriage, Proposition 8, could not defend it before the Supreme Court. (Photo by Kevork Djansezian/Getty Images)

SAN FRANCISCO, CA - JUNE 26: Supporters of same-sex marriage cheer as they learn results of the U.S. Supreme Court's rulings on gay marriage in City Hall June 26, 2013 in San Francisco, United States. The high court struck down the Defense of Marriage Act (DOMA) and ruled that supporters of California's ban on gay marriage, Proposition 8, could not defend it before the Supreme Court. (Photo by Justin Sullivan/Getty Images)

SAN FRANCISCO, CA - JUNE 26: Same-sex couple Sue Rochman (L) and Robin Romdalvik celebrate upon hearing the U.S. Supreme Court's rulings on gay marriage in City Hall June 26, 2013 in San Francisco, United States. The high court struck down the Defense of Marriage Act (DOMA) and ruled that supporters of California's ban on gay marriage, Proposition 8, could not defend it before the Supreme Court. (Photo by Justin Sullivan/Getty Images)

Gay rights activists reacts outside the US Supreme Court building in Washington DC on June 26, 2013, after the court ruling on California's Proposition 8, the controversial ballot initiative that defines marriage as between a man and a woman. AFP PHOTO / MLADEN ANTONOV (Photo credit should read MLADEN ANTONOV/AFP/Getty Images)

WEST HOLLYWOOD, CA - JUNE 26: Erica Ikeda (C), 26, and her friends react to the Supreme Court ruling at a watch party at Equality California, a non-profit civil rights organization that advocates for the rights of LGBT people in California, on June 26, 2013 in West Hollywood, California. The high court struck down the Defense of Marriage Act (DOMA) and ruled that supporters of California's ban on gay marriage, Proposition 8, could not defend it before the Supreme Court. (Photo by Kevork Djansezian/Getty Images)

John Lewis, left, gets a kiss from his partner Stuart Gaffney as they embrace after the Supreme Court cleared the way for same-sex marriage in California at the office of San Francisco Mayor Ed Lee at City Hall in San Francisco, Wednesday, June 26, 2013. The justices issued two 5-4 rulings in their final session of the term. One decision wiped away part of a federal anti-gay marriage law that has kept legally married same-sex couples from receiving tax, health and pension benefits. The other was a technical legal ruling that said nothing at all about same-sex marriage, but left in place a trial court's declaration that California's Proposition 8 is unconstitutional. (AP Photo/Jeff Chiu)

WASHINGTON, DC - JUNE 26: Plaintiff couple Sandy Stier (C) and Kris Perry (L) arrive for their Proposition 8 case before the U.S. Supreme Court on June 26, 2013 in Washington, DC. The high court is expected to rule on the DOMA and Prop 8 gay marriage cases. (Photo by Win McNamee/Getty Images)

WASHINGTON, DC - JUNE 26: Gay rights supporters Brian Sprague (L) and Charlie Ferrusi, from Albany, New York, hold a Human Rights flag outside U.S. Supreme Court building on June 26, 2013 in Washington, DC. The high court is expected to rule on the DOMA and Prop 8 gay marriage cases. (Photo by Win McNamee/Getty Images)

WASHINGTON, DC - JUNE 26: Gay rights supporter Vin Testa waves a rainbow flag outside the U.S. Supreme Court building on June 26, 2013 in Washington, DC. The high court is expected to rule on the DOMA and Prop 8 gay marriage cases. (Photo by Win McNamee/Getty Images)

Gay rights activists gather outside the US Supreme Court building in Washington, DC on June 26, 2013. The US Supreme Court on Wednesday struck down a controversial federal law that defines marriage as a union between a man and a woman, in a major victory for supporters of same-sex marriage.The Defense of Marriage Act (DOMA) had denied married gay and lesbian couples in the United States the same rights and benefits that straight couples have long taken for granted. AFP PHOTO / MLADEN ANTONOV (Photo credit should read MLADEN ANTONOV/AFP/Getty Images)

American University students Sharon Burk, left, and Molly Wagner, embrace outside the Supreme Court in Washington, Wednesday, June 26, 2013, after the court cleared the way for same-sex marriage in California by holding that defenders of California's gay marriage ban did not have the right to appeal lower court rulings striking down the ban. (AP Photo/Charles Dharapak)

Arriving at the Supreme Court in Washington, Wednesday, June 26, 2013, on a final day for decisions in two gay marriage cases are plaintiffs in the California Proposition 8 case, from left, Paul Katami, his partner Jeff Zarrillo, and Sandy Stier and her partner Kris Perry. (AP Photo/J. Scott Applewhite)

Michael Knaapen, left, and his husband John Becker, right, embrace outside the Supreme Court in Washington, Wednesday, June 26, 2013 after the court struck down a federal provision denying benefits to legally married gay couples. (AP Photo/Charles Dharapak)

American University students Sharon Burk, left, and Molly Wagner participate in a rally for rights for gay couples in front of the Supreme Court in Washington, Wednesday, June 26, 2013, after the court cleared the way for same-sex marriage in California by holding that defenders of California's gay marriage ban did not have the right to appeal lower court rulings striking down the ban. (AP Photo/Charles Dharapak)

Supporters of gay marriage embrace outside the Supreme Court in Washington, Wednesday, June 26, 2013, after the court cleared the way for same-sex marriage in California by holding that defenders of California's gay marriage ban did not have the right to appeal lower court rulings striking down the ban. (AP Photo/Charles Dharapak)

Sen. Richard Blumenthal (D-Conn.) spotted in the crowd during the SCOTUS decisions on June 26

Source: http://www.huffingtonpost.com/2013/06/26/defense-of-marriage-act-supreme-court_n_3454846.html

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Miesha Tate to pose nude in ESPN the Magazine

UFC bantamweight Miesha Tate is joining the ranks of MMA fighters who have posed nude in ESPN the Magazine's Body Issue. The magazine announced today that Tate will appear in the yearly issue that shows off athletes' bodies. It will hit newsstands on July 12.

Tate's opposing coach on the upcoming season of "The Ultimate Fighter," UFC women's bantamweight champion Ronda Rousey, was on last season's cover. Both women appearing in the magazine will give them one more thing to trash talk about as they film the TUF that will air in September.

[Related: Mets' Matt Harvey to flaunt curves in 'Body Issue']

UFC president Dana White said the filming is filled with their squabbles every day.

"It's going exactly the way you thought it would be going: bad," White said. "Dead serious. Miesha and Ronda hate each other. It's literally crazy drama every day. It's irritating."

Other fighters who have been in the Body Issue include Jon Jones and Gina Carano.

Related coverage on Yahoo! Sports:
? Native American fighter Dan Hornbuckle more than a face in the crowd
? Is Chris Weidman the one to take out Anderson Silva?
? Ricardo Lamas depending on family to get over disappointing pursuit of UFC belt

Source: http://sports.yahoo.com/blogs/mma-cagewriter/miesha-tate-pose-nude-espn-magazine-201403709.html

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Digital Workshop: Searching in Windows 8

Holland America Blog Has Just Posted the Following:

Special thanks to Zuiderdam?s Techspert Krista who posted this on HAL?s Digital Workshop blog. Today I wanted to share some hints about searching in Windows 8. I loved searching in Windows 7. It was a fast and easy way to find anything I needed. Searching in Windows 8 is a little different, but just as [...]

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Source: http://www.cruise-addicts.com/forums/f43/digital-workshop-searching-windows-8-a-206718-new/

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